Ovarian Cancer Treatment in Germany

Ovarian cancer is a significant global health concern, ranking as the eighth most common cancer among women. In 2022, there were approximately 324,603 new cases worldwide, with over 206,000 related deaths. [1] The disease often presents with non-specific symptoms, leading to late-stage diagnoses and a global five-year survival rate ranging between 36% and 46%. [2]

In Germany, ovarian cancer remains a serious issue, with 7,547 new cases reported in 2022. [1] However, the country's healthcare system has invested in early detection and advanced treatment options, contributing to a relative five-year survival rate of approximately 44%. It is important to note that the five-year survival rate can reach up to 90% when diagnosed at stage I. [3]

In general, Germany is known for its excellent medical care, modern facilities, and adherence to international treatment protocols. In this country, patients benefit from multidisciplinary teams, personalized treatment plans, and access to innovative therapies. For individuals seeking comprehensive ovarian cancer care, Germany offers a combination of medical expertise and compassionate support, making it a leading choice for treatment.

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What Is Ovarian Cancer?

Ovarian cancer is a malignancy originating in the ovaries, often termed the "silent killer" due to its subtle early symptoms that frequently lead to late-stage diagnoses. [4]

Types of Ovarian Cancer

Ovarian cancers are categorized based on the originating cell type:

1. Epithelial tumors: These arise from the cells covering the ovary's surface and constitute approximately 90% of ovarian cancers. [5, 6] Subtypes include:

• High-grade serous carcinoma: The most prevalent and aggressive form.
• Low-grade serous carcinoma: Less common and slower-growing.
• Endometrioid carcinoma: Often linked with endometriosis.
• Clear cell carcinoma: Associated with endometriosis and more resistant to chemotherapy.
• Mucinous carcinoma: Rare and typically diagnosed at an earlier stage.

2. Germ cell tumors: These rare tumors originate from the cells that produce eggs and account for about 2% of ovarian cancers. [6] They predominantly affect younger women and include subtypes like dysgerminomas and yolk sac tumors. [5, 6]
3. Sex cord-stromal tumors: Developing from the ovarian connective tissue, these tumors are uncommon and often produce hormones. Examples include granulosa cell tumors and Sertoli-Leydig cell tumors. [5-7]

Stages of Ovarian Cancer

The progression of ovarian cancer is classified into four stages:

• Stage I: Cancer is confined to one or both ovaries.
• Stage II: Cancer has spread to pelvic organs.
• Stage III: Cancer has extended to the abdominal cavity or lymph nodes.
• Stage IV: Cancer has metastasized to distant organs, such as the liver or lungs.

Early-stage detection significantly improves survival rates. For example, the five-year survival rate is approximately 89% for Stage I and 71% for Stage II. However, due to the often asymptomatic nature of early ovarian cancer, about 75% of cases are diagnosed at advanced stages, where survival rates drop to 40% for Stage III and 20% for Stage IV. [6, 8]

Unfortunately, there is currently no reliable screening test for early-stage ovarian cancer. Therefore, it is vital to be aware of symptoms such as persistent bloating, pelvic or abdominal pain, and changes in urinary habits.

Why Choose Germany for Ovarian Cancer Treatment?

Germany's healthcare system is characterized by high medical standards, ensuring that patients receive exceptional treatment options for ovarian cancer.

Advantages of ovarian cancer treatment in Germany include:

• High medical standards: German hospitals adhere to strict quality protocols, often being certified by organizations like the German Cancer Society.
• Advanced technology: Facilities are equipped with modern diagnostic and treatment tools, including PET/CT scanners for precise imaging and robotic surgical systems that allow for minimally invasive procedures.
• Experienced specialists: Germany provides access to the best oncologists and gynecologic oncology departments.
• Access to clinical trials and innovative treatments: Patients have the opportunity to participate in clinical trials exploring innovative therapies for ovarian cancer in Germany, such as targeted therapies and immunotherapies.
• Personalized treatment approaches: German medical centers emphasize individualized care plans, tailoring treatments based on genetic profiling and molecular diagnostics to optimize outcomes for each patient.

In other words, choosing Germany for treatment of ovarian cancer means benefiting from a healthcare system that combines technological innovation with patient-centered care, aiming to improve survival rates and quality of life for patients worldwide.

Standard Treatment Options in Germany

Germany offers an advanced approach to ovarian cancer treatment, integrating standard therapies with innovative techniques to improve patient outcomes. Below is an overview of the primary treatment modalities available in German medical centers.

Surgery

Ovarian cancer surgery in Germany is a primary method in the management of the disease, aiming to remove as much of the tumor mass as possible. German hospitals specialize in both extensive debulking surgeries and minimally invasive procedures, depending on the cancer stage and patient health.

• Debulking surgery: This involves the removal of visible tumor tissues and may include the ovaries, uterus, fallopian tubes, and affected surrounding tissues.
• Minimally invasive surgery: Laparoscopic approaches are increasingly utilized, offering reduced recovery times and fewer complications.

A nationwide analysis indicated that approximately 85% of ovarian cancer surgeries in Germany were performed via laparotomy, with a growing trend towards laparoscopy, which showed a lower in-hospital mortality rate of 0.4% compared to 2.9% for open surgeries. [9]

Chemotherapy

Chemotherapy is typically administered post-surgery to target residual cancer cells. German oncology centers implement advanced chemotherapy strategies that emphasize both effectiveness and patient well-being.

Main features of chemotherapy for ovarian cancer in Germany include:

• Cycle-based treatment: Allows healthy cells time to recover and minimizes toxicity.
• Dose-dense scheduling: Administers smaller doses more frequently for improved outcomes in select cases.
• Combination with innovative techniques: Chemotherapy is often integrated with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) during surgery for enhanced local effect.

German clinics are internationally recognized for their expertise in delivering chemotherapy as part of an integrated, patient-centered cancer care strategy.

Targeted Therapy

Targeted therapy has transformed ovarian cancer treatment by focusing on specific biological mechanisms that allow cancer cells to grow and spread. Unlike traditional chemotherapy, targeted therapies aim to minimize damage to healthy tissues while disrupting cancer development.

In Germany, targeted therapies are a part of advanced ovarian cancer treatment strategies, often used alongside or after initial treatments to extend remission periods and improve survival rates.

Targeted therapy for ovarian cancer in Germany is characterized by:

• Precision treatment: Targets specific proteins or pathways involved in cancer cell growth and survival.
• Reduced side effects: Focuses on cancer cells while minimizing harm to normal cells.
• Extended remission: Helps delay the progression of disease after initial treatments.
• Integration with standard therapies: Often used in combination with surgery or chemotherapy for a more comprehensive treatment strategy.

German clinics emphasize the use of targeted therapy as part of a personalized, precision medicine approach, offering patients access to the latest advancements in clinical oncology.

Radiotherapy

While not commonly used as a primary treatment for ovarian cancer, radiotherapy is applied as a palliative measure to manage symptoms, such as pain or bleeding, in advanced stages.

• Palliative radiotherapy: Applied to alleviate symptoms and improve quality of life in patients with metastatic disease.

Advancements in radiotherapy techniques, such as helical tomotherapy, have improved the precision of treatment, minimizing damage to surrounding healthy tissues.

Innovative and Advanced Therapies

HIPEC (Hyperthermic Intraperitoneal Chemotherapy)

HIPEC is an advanced treatment modality where heated chemotherapy is administered directly into the abdominal cavity immediately after cytoreductive surgery. This approach aims to eradicate residual cancer cells, particularly beneficial for patients with advanced-stage ovarian cancer.

In Germany, HIPEC is available in specialized centers and has shown promising results. A study reported a median survival of 35 months for patients who underwent complete tumor resection followed by HIPEC and systemic therapy. However, the efficacy of HIPEC can vary, and some studies suggest its benefits are most pronounced in patients with minimal residual disease. [10, 11]

Immunotherapy: Dendritic Cell Therapy

Dendritic cell-based immunotherapy represents a personalized approach to treating ovarian cancer. This therapy involves extracting a patient's dendritic cells, exposing them to tumor antigens, and reintroducing them to stimulate an immune response against cancer cells. 

The significance of dendritic cells in immunotherapy was recognized when Ralph Steinman received the Nobel Prize in Physiology or Medicine in 2011 for his discovery of these cells. In clinical settings, dendritic cell therapy has demonstrated a favorable safety profile and potential benefits. For example, a phase II trial combining dendritic cell vaccine (DCVAC/OvCa) with chemotherapy showed a median overall survival prolongation of 13.4 months compared to chemotherapy alone. [12]

Personalized Medicine

Personalized medicine in ovarian cancer involves tailoring treatment strategies based on the genetic and molecular characteristics of a patient's tumor. This approach utilizes comprehensive genomic profiling to identify actionable mutations and biomarkers, enabling clinicians to select targeted therapies that are more effective and have fewer side effects. 

In Germany, a significant proportion of medical centers have adopted personalized medicine practices. A survey indicated that 67.4% of respondents offered genetic testing to more than 80% of patients with newly diagnosed ovarian cancer. [13] This integration of molecular diagnostics into clinical decision-making enhances the precision of treatment plans and improves patient outcomes.

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Top Clinics and Oncologists in Germany

Below are three top hospitals for ovarian cancer in Germany, recognized for their innovative approaches in gynecologic oncology.

Asklepios Hospital Barmbek is located in Hamburg. It is known for its comprehensive gynecologic oncology department. Led by Dr. Michael Lipp, the team specializes in advanced surgical procedures, including minimally invasive and cytoreductive surgeries for ovarian cancer. The hospital demonstrates high success rates and adherence to international oncology protocols.

LDG Laboratories Dr. Gansauge, headed by Dr. Frank Gansauge, offers innovative dendritic cell therapy, making it a leader in immunotherapy for ovarian cancer. The center focuses on personalized treatment approaches and has been instrumental in advancing cell-based therapies. It is a top choice for patients seeking innovative options beyond standard chemotherapy and surgery.

University Hospital Essen deserves mention for its role in robotic-assisted gynecologic surgeries. Prof. Dr. Klaus Rainer Kimmig, a world-leading surgeon, heads the department. His expertise in robotic techniques offers patients less invasive options with faster recovery times and improved outcomes.

Patient Story: Gretta Gasparian's Experience

Germany is a leader in advanced ovarian cancer treatment, with its innovative therapies and exceptional oncology centers. The country attracts patients from around the globe seeking the best possible care.

Gretta Gasparian was diagnosed with stage 4 ovarian cancer. She traveled from Russia to receive dendritic cell therapy at LDG Laboratories Dr. Gansauge. Accompanied by Booking Health, she quickly secured an appointment at this center. Throughout her treatment journey, Gretta praised the team for their support, from assistance with medical documentation and visa arrangements to on-site interpretation services. Under the personalized care of Dr. Gansauge, she underwent dendritic cell immunotherapy. Gretta now feels significantly better, with improved energy levels and fewer symptoms. She is optimistic about her recovery and encourages everyone struggling with ovarian cancer to remain hopeful.

Treatment Costs

The cost of ovarian cancer treatment in Germany varies depending on the selected therapies and the hospital. German clinics are known for their transparency and high-quality care, providing detailed treatment plans and cost estimates. Below is an overview of typical treatment costs:

*Booking Health data

Patients considering advanced treatment for ovarian cancer abroad often compare countries based on technology, access to innovation, and cost. Here is a comparison of Germany with other popular medical tourism destinations:

Medical Procedures Costs for Ovarian Cancer

*Prices may vary depending on the course of treatment and tumor characteristics

Medical Travel Support for Ovarian Cancer with Booking Health

Germany is a leading destination for ovarian cancer treatment, offering advanced medical technologies, internationally recognized oncologists, and superior success rates. Patients benefit from modern hospitals equipped with modern facilities and innovative therapies, such as HIPEC and dendritic cell immunotherapy, which are not widely available elsewhere. The integration of personalized treatment approaches ensures optimal outcomes and improved quality of life.

Booking Health provides comprehensive support for international patients, handling every aspect of their medical journey. This includes arranging consultations and hospital admissions, assisting with documentation and visa services, and providing professional medical translation. With Booking Health, patients can focus on their recovery while all logistical concerns are professionally managed.

Our services include:

• Assessment and analysis of medical reports
• Development of the medical care program
• Selection of a suitable treatment location
• Preparation of medical documents and forwarding to a suitable clinic
• Preparatory consultations with clinicians for the development of medical care programs
• Professional advice during the hospital stay
• Follow-up care after the patient returns to their native country after completing the medical care program
• Taking care of formalities as part of the preparation for the medical care program
• Coordination and organization of the patient's stay in a foreign country
• Assistance with visas and tickets
• A personal coordinator and interpreter with 24/7 support
• Transparent budgeting with no hidden costs

Contact Booking Health today for a personalized consultation and start your journey to effective ovarian cancer treatment in Germany.

Modern Cancer Treatment: Patient Journeys with Booking Health

Eliza A. (Armenia), June 2025

Maria S. (Sweden), November 2024

Gretta G. (Armenia), January 2024

Suzanne L. OD. (United Kingdom), April 2023

Suzanne L. OD. (United Kingdom), April 2023

Choose treatment abroad and you will for sure get the best results!

Authors:

This article was edited by medical experts, board-certified doctors Dr. Nadezhda Ivanisova, and Dr. Bohdan Mykhalniuk. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

Our editorial policy, which details our commitment to accuracy and transparency, is available here. Click this link to review our policies.

Sources:

[1] World Cancer Research Fund. Ovarian Cancer Statistics. Published 2024. https://www.wcrf.org/preventing-cancer/cancer-statistics/ovarian-cancer-statistics/

[2] World Ovarian Cancer Coalition. Ovarian Cancer Key Stats. Published 2022. https://worldovariancancercoalition.org/about-ovarian-cancer/key-stats/

[3] Robert Koch Institut. Ovarian Cancer. Published 2020. https://www.krebsdaten.de/Krebs/EN/Content/Cancer_sites/Ovarian_cancer/ovarian_cancer_node.html

[4] ScienceDirect. Trends in the incidence and mortality of cervical, ovarian, and corpus uteri cancers in Wales, UK: A joinpoint regression analysis from 2002 to 2021. https://www.sciencedirect.com/science/article/abs/pii/S1877782124001395?via%3Dihub

[5] Ovarian Cancer Research Alliance. Ovarian Cancer. Published 2024. https://ocrahope.org/for-patients/gynecologic-cancers/ovarian-cancer/

[6] Ovarian.org. Types and Stages. Published 2024. https://ovarian.org/about-ovarian-cancer/types-and-stages/

[7] American Cancer Society. What is Ovarian Cancer. Ovarian Tumors and Cysts. Published 2024. https://www.cancer.org/cancer/types/ovarian-cancer/about/what-is-ovarian-cancer.html

[8] UT Health San Antonio. Ovarian Cancer: Early Detection Can Help Save Lives. Published 2023. https://news.uthscsa.edu/ovarian-cancer-early-detection-can-help-save-lives/

[9] Sage Journals. Ovarian cancer surgery in Germany: An analysis of the nationwide hospital file 2005–2015. https://journals.sagepub.com/doi/10.1177/17455065221075903

[10] Journal of Gynecologic Oncology. Expert commentary on HORSE/MITO18 and CHIPOR. https://ejgo.org/DOIx.php?id=10.3802/jgo.2025.36.e87

[11] ScienceDirect. Statement of the AGO Kommission Ovar, AGO Study Group, NOGGO, AGO Austria, Swiss AGO, BGOG, CEEGOG, GEICO, and SFOG regarding the use of hyperthermic intraperitoneal chemotherapy (HIPEC) in epithelial ovarian cancer. https://www.sciencedirect.com/science/article/abs/pii/S000745512300098X?via%3Dihub

[12] Gynecologic Oncology. Dendritic cell-based immunotherapy (DCVAC/OvCa) combined with second-line chemotherapy in platinum-sensitive ovarian cancer (SOV02): A randomized, open-label, phase 2 trial. https://www.gynecologiconcology-online.net/article/S0090-8258(21)00533-3/fulltext

[13] International Journal of Gynecological Cancer. Survey on implementation of molecular testing in ovarian cancer and PARP inhibitor: a national North-Eastern German Society of Gynecologic Oncology/Young Academy of Gynecologic Oncology/Arbeitsgemeinschaft Gynäkologische Onkologie intergroup analysis. https://www.international-journal-of-gynecological-cancer.com/article/S1048-891X(24)00693-5/fulltext

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